Commentary for I Samuel 5:6
וַתִּכְבַּ֧ד יַד־יְהוָ֛ה אֶל־הָאַשְׁדּוֹדִ֖ים וַיְשִׁמֵּ֑ם וַיַּ֤ךְ אֹתָם֙ בעפלים [בַּטְּחֹרִ֔ים] אֶת־אַשְׁדּ֖וֹד וְאֶת־גְּבוּלֶֽיהָ׃
But the hand of the LORD was heavy upon them of Ashdod, and He destroyed them, and smote them with emerods, even Ashdod and the borders thereof.
Rashi on I Samuel
And He devastated them. An expression [שְׁמָמָה] meaning desolation.
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Rashi on I Samuel
With hemorrhoids. The mesentery of the large intestine, a plague of the rectum. Mice would enter their recta, disembowel them, and crawl out.
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